Delta Airlines will suspend its flights between New York JFK Airport and the Murtala Muhammed International Airport, Lagos from 4 October.
The airline said the halt was to fit into “the current demand environment.”
In a statement released on Tuesday, Delta noted that it will continue “to operate service between Lagos and Atlanta” and offer connections to New York and other cities across the United States.
It said customers impacted by the flight suspension will be re-accommodated on Delta-operated flights or services operated by its joint venture partners.
The New York-Lagos direct flight is one of many Delta Airlines is cutting this year.
In May, the airline announced it was going to cut 100 flights a day from its schedule, many of them in the United States and Latin America.
It cited "rebuilding Delta's full-scale operation" as the reason, no thanks to soaring fuel prices pushed up by the uncertainties caused by Russia's invasion of Ukraine.
But Delta and other international airlines have faced a unique challenge in Nigeria, in addition to petroleum prices.
The Nigerian government blocked the repatriation of some $460 million in the revenue of foreign airlines in a move to preserve scarce foreign exchange and control the exchange rate.
This led to airlines threatening to suspend flights to and from the country.
Last week, the Central Bank of Nigeria released $265 million of the funds to the airlines.